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Engineered γδ T cells show promise in bone tumours
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-06-11 , DOI: 10.1038/s41577-024-01056-y Alexandra Flemming 1
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-06-11 , DOI: 10.1038/s41577-024-01056-y Alexandra Flemming 1
Affiliation
An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, controlled tumour growth in a mouse model of patient-derived osteosarcoma.
中文翻译:
工程化 γδ T 细胞在骨肿瘤中显示出前景
一种基于 γδ T 细胞的过继细胞疗法控制了患者来源的骨肉瘤小鼠模型中的肿瘤生长,γδ T 细胞被设计为分泌肿瘤靶向调理素以及 IL-15 超级激动剂。
更新日期:2024-06-11
中文翻译:
工程化 γδ T 细胞在骨肿瘤中显示出前景
一种基于 γδ T 细胞的过继细胞疗法控制了患者来源的骨肉瘤小鼠模型中的肿瘤生长,γδ T 细胞被设计为分泌肿瘤靶向调理素以及 IL-15 超级激动剂。