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A novel function of the M2 muscarinic receptor
Trends in Pharmacological Sciences ( IF 13.9 ) Pub Date : 2024-06-08 , DOI: 10.1016/j.tips.2024.05.010
Jürgen Wess , Liu Liu

The M2 muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M2 receptor mRNA, directing the expression of a C-terminal receptor fragment. Elevated during cellular stress, this polypeptide localizes to mitochondria where it inhibits oxidative phosphorylation.



中文翻译:


M2毒蕈碱受体的新功能



M 2 毒蕈碱受体 (M2R) 是一种原型 A 类 G 蛋白偶联受体 (GPCR)。有趣的是,法夏尼等人。最近在 M 2 受体 mRNA 内发现了一个内部翻译起始位点,指导 C 端受体片段的表达。该多肽在细胞应激期间升高,定位于线粒体,抑制氧化磷酸化。

更新日期:2024-06-11
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