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Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche
Developmental Cell ( IF 10.7 ) Pub Date : 2024-06-11 , DOI: 10.1016/j.devcel.2024.05.020 Felipe S Rodrigues 1 , Adam Karoutas 1 , Stefanie Ruhland 1 , Nicolas Rabas 1 , Tatiana Rizou 1 , Stefania Di Blasio 1 , Rute M M Ferreira 1 , Victoria L Bridgeman 1 , Robert Goldstone 2 , Miriam L Sopena 2 , Joo-Hyeon Lee 3 , Luigi Ombrato 4 , Ilaria Malanchi 1
Developmental Cell ( IF 10.7 ) Pub Date : 2024-06-11 , DOI: 10.1016/j.devcel.2024.05.020 Felipe S Rodrigues 1 , Adam Karoutas 1 , Stefanie Ruhland 1 , Nicolas Rabas 1 , Tatiana Rizou 1 , Stefania Di Blasio 1 , Rute M M Ferreira 1 , Victoria L Bridgeman 1 , Robert Goldstone 2 , Miriam L Sopena 2 , Joo-Hyeon Lee 3 , Luigi Ombrato 4 , Ilaria Malanchi 1
Affiliation
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A key step for metastatic outgrowth involves the generation of a deeply altered microenvironment (niche) that supports the malignant behavior of cancer cells. The complexity of the metastatic niche has posed a significant challenge in elucidating the underlying programs driving its origin. Here, by focusing on early stages of breast cancer metastasis to the lung in mice, we describe a cancer-dependent chromatin remodeling and activation of developmental programs in alveolar type 2 (AT2) cells within the niche. We show that metastatic cells can prime AT2 cells into a reprogrammed multilineage state. In turn, this cancer-induced reprogramming of AT2 cells promoted stem-like features in cancer cells and enhanced their initiation capacity. In conclusion, we propose the concept of “reflected stemness” as an early phenomenon during metastatic niche initiation, wherein metastatic cells reprogram the local tissue into a stem-like state that enhances intrinsic cancer-initiating potential, creating a positive feedback loop where tumorigenic programs are amplified.
中文翻译：
生态位内转移性癌症和肺泡 2 型细胞之间的干细胞样程序的双向激活
转移性生长的一个关键步骤涉及产生一个深度改变的微环境（生态位），以支持癌细胞的恶性行为。转移生态位的复杂性为阐明驱动其起源的潜在程序带来了重大挑战。在这里，通过关注小鼠乳腺癌转移到肺部的早期阶段，我们描述了壁龛内肺泡 2 型 （AT2） 细胞中癌症依赖性染色质重塑和发育程序的激活。我们表明转移细胞可以引发 AT2 细胞进入重编程的多谱系状态。反过来，这种癌症诱导的 AT2 细胞重编程促进了癌细胞中的干细胞样特征并增强了它们的起始能力。总之，我们提出了“反射干性”的概念作为转移性生态位启动过程中的早期现象，其中转移细胞将局部组织重新编程为干状状态，从而增强内在的癌症启动潜力，从而创建一个正反馈回路，致瘤程序被放大。
更新日期：2024-06-11
中文翻译：
生态位内转移性癌症和肺泡 2 型细胞之间的干细胞样程序的双向激活
转移性生长的一个关键步骤涉及产生一个深度改变的微环境（生态位），以支持癌细胞的恶性行为。转移生态位的复杂性为阐明驱动其起源的潜在程序带来了重大挑战。在这里，通过关注小鼠乳腺癌转移到肺部的早期阶段，我们描述了壁龛内肺泡 2 型 （AT2） 细胞中癌症依赖性染色质重塑和发育程序的激活。我们表明转移细胞可以引发 AT2 细胞进入重编程的多谱系状态。反过来，这种癌症诱导的 AT2 细胞重编程促进了癌细胞中的干细胞样特征并增强了它们的起始能力。总之，我们提出了“反射干性”的概念作为转移性生态位启动过程中的早期现象，其中转移细胞将局部组织重新编程为干状状态，从而增强内在的癌症启动潜力，从而创建一个正反馈回路，致瘤程序被放大。
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