Induced proximity labeling and editing for epigenetic research,Cell Chemical Biology

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Induced proximity labeling and editing for epigenetic research
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2024-06-11 , DOI: 10.1016/j.chembiol.2024.05.005
Chenwei Zhou ₁ , Sarah Wagner ₁ , Fu-Sen Liang ₁

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Epigenetic regulation plays a pivotal role in various biological and disease processes. Two key lines of investigation have been pursued that aim to unravel endogenous epigenetic events at particular genes (probing) and artificially manipulate the epigenetic landscape (editing). The concept of induced proximity has inspired the development of powerful tools for epigenetic research. Induced proximity strategies involve bringing molecular effectors into spatial proximity with specific genomic regions to achieve the probing or manipulation of local epigenetic environments with increased proximity. In this review, we detail the development of induced proximity methods and applications in shedding light on the intricacies of epigenetic regulation.

中文翻译：

用于表观遗传学研究的诱导邻近标记和编辑

表观遗传调控在各种生物和疾病过程中起着关键作用。已经采取了两条关键的研究路线，旨在揭示特定基因的内源性表观遗传事件（探测）和人为操纵表观遗传景观（编辑）。诱导接近的概念激发了表观遗传学研究强大工具的开发。诱导接近策略包括将分子效应子带入与特定基因组区域的空间接近，以实现对局部表观遗传环境的探测或操作，同时增加接近度。在这篇综述中，我们详细介绍了诱导接近方法的发展和应用，阐明了表观遗传调控的复杂性。

更新日期：2024-06-11

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