Oximes are crucial in several areas such as synthetic chemistry, medicinal chemistry, and materials science. In this context, we have developed a general photochemical approach for synthesizing diverse oximes without catalysts. Our protocol demonstrated broad applicability in various alkene oximation reactions, such as phosphoryloximation, sulfonyloximation, and trifluoromethyl-oximation. Furthermore, this protocol could be extended to obtain alkenyl and alkynyl phosphine oxides. Characterized by its mild conditions, broad substrate compatibility, straightforward operation, and scalability, our synthetic strategy stands out. The simple and modular method offers a new perspective for chemists to rapidly obtain various radical intermediates in an environmentally friendly and sustainable way.

中文翻译：

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无催化剂情况下活化烯烃肟化的通用光化学策略


肟在合成化学、药物化学和材料科学等多个领域至关重要。在这种背景下，我们开发了一种无需催化剂即可合成各种肟的通用光化学方法。我们的方案在各种烯烃肟化反应中表现出广泛的适用性，例如磷酰肟化、磺酰肟化和三氟甲基肟化。此外，该方案可以扩展以获得烯基和炔基氧化膦。我们的合成策略以其温和的条件、广泛的底物兼容性、简单的操作和可扩展性为特点，脱颖而出。这种简单且模块化的方法为化学家以环保和可持续的方式快速获得各种自由基中间体提供了新的视角。