Veratrum steroidal alkaloids are highly intricate alkaloids with a C-nor-D-homo steroid skeleton linked to a piperidine ring. These alkaloids have fascinated researchers due to their structural complexity and biological properties. The first synthesis of cyclopamine was accomplished in 2009 via a semi-synthetic approach. More recently, the synthesis of Veratrum steroidal alkaloids has made significant progress, employing a convergent approach. In this Highlight, we discuss the synthetic strategy that yields the highly functionalized, complex molecular architecture of Veratrum steroidal alkaloids, emphasizing key reactions involved. We also explore the current state of the synthesis of Veratrum steroidal alkaloids and discuss future directions and opportunities for the convergent synthetic approach in complex natural product synthesis.

中文翻译：

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藜芦甾体生物碱的战略聚合合成


藜芦甾体生物碱是高度复杂的生物碱，具有与哌啶环连接的 C-nor-D-同型类固醇骨架。这些生物碱因其结构复杂性和生物特性而令研究人员着迷。环巴明的首次合成于 2009 年通过半合成方法完成。最近，藜芦甾体生物碱的合成采用收敛方法取得了重大进展。在本次重点报道中，我们讨论了藜芦甾体生物碱的高度功能化、复杂的分子结构的合成策略，并强调了所涉及的关键反应。我们还探讨了藜芦甾体生物碱合成的现状，并讨论了复杂天然产物合成中聚合合成方法的未来方向和机遇。