In this issue of Cancer Cell, Zhong et al. explore the dual role of TREM2 in glioblastoma-associated myeloid cells, demonstrating its function in promoting inflammation at the tumor-neural interface and suppression within the tumor core, influenced by the local microenvironment. These findings open up promising prospects for advancements in neuro-oncological immunotherapy.

中文翻译：

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绘制骨髓细胞功能：肿瘤和神经元微环境的空间多样性

在本期《癌细胞》中，Zhong 等人。探索 TREM2 在胶质母细胞瘤相关骨髓细胞中的双重作用，证明其在受局部微环境影响下促进肿瘤神经界面炎症和抑制肿瘤核心内炎症的功能。这些发现为神经肿瘤免疫治疗的进步开辟了广阔的前景。