Imidazo/Benzimidazo[1,2-c]quinazoline is a planar trinitrogen heteroarene that contains both imidazole/benzimidazole and quinazoline moiety fused together by a common link. Not surprisingly, imidazo/benzimidazo[1,2-c]quinazoline is an privileged scaffold with diverse applications in biological and medicinal studies, as many molecules containing this framework exhibit a wide range of therapeutic activities, such as DNA intercalator, anticancer, antitumor, antibacterial, antiviral, anti-inflammatory, anticonvulsant and α-glucosidase inhibitory properties. In addition to its physiological applications, this moiety has been investigated for electrical conductivity, molecules/ions sensing, coordination complex and coordination polymer (CP) formation, and their diverse applications. As a consequence, enormous efforts have been expended in order to construct such a skeleton. This review compiles recent research methodologies and various applications of the imidazo/benzimidazo[1,2-c]quinazoline moiety reported in peer-reviewed journals.

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咪唑/苯并咪唑[1,2-c]喹唑啉当前合成方法和应用的广泛分析


咪唑/苯并咪唑[1,2-c]喹唑啉是一种平面三氮杂芳烃，包含通过共同连接融合在一起的咪唑/苯并咪唑和喹唑啉部分。毫不奇怪，咪唑/苯并咪唑[1,2-c]喹唑啉是一种在生物和医学研究中具有多种应用的特殊支架，因为许多含有该框架的分子表现出广泛的治疗活性，例如DNA嵌入剂、抗癌、抗肿瘤、抗菌、抗病毒、抗炎、抗惊厥和 α-葡萄糖苷酶抑制特性。除了其生理学应用之外，该部分还被研究用于导电性、分子/离子传感、配位复合物和配位聚合物 (CP) 形成及其多种应用。因此，为了构建这样的骨架，已经花费了巨大的努力。本综述汇集了同行评审期刊中报道的咪唑并/苯并咪唑[1,2-c]喹唑啉部分的最新研究方法和各种应用。