An enantioselective arylation of isoxazoles with N-Cbz-protected azonaphthalenes is disclosed, affording a range of axially chiral arylisoxazoles in good yields and excellent enantiocontrol by utilizing chiral phosphoric acid. Cbz protecting group can be readily removed, resulting in five-six membered axially chiral heterobiaryl amines bearing free amine maintaining enantiomeric purity.

中文翻译：

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通过 5-氨基异恶唑的有机催化芳基化对映选择性合成轴向手性杂联芳基 N-Cbz 保护的二胺


公开了异恶唑与 N-Cbz 保护的偶氮萘的对映选择性芳基化，通过利用手性磷酸以良好的产率和优异的对映体控制提供了一系列轴向手性芳基异恶唑。 Cbz 保护基团可以很容易地去除，从而产生带有游离胺的五六元轴向手性杂联芳胺，保持对映体纯度。