The most challenging aspect of chemical synthesis has always been attainment of high chemoselectivity levels. This review will provide a panoramic view on how the innate reactivity of two nearly reactive functional groups (-O/-N) can be controlled or reversed for the chemoselective functionalisation in alkanolamines. A comprehensive compilation of reports encasing various methodologies developed to accomplish selective O/N functionalisation in amino alcohols has been documented. In this review, we go over a number of findings that have been studied in recent decades using a variety of synthetic approaches. To help us organize and emphasize the important ideas that have been emerging as a result of these research, we have concentrated on the suggested mechanistic basis of the reactions that are being surveyed.

中文翻译：

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控制烷醇胺化学选择性的因素：全景概述


化学合成最具挑战性的方面始终是达到高化学选择性水平。本综述将全面介绍如何控制或逆转两个近反应性官能团 (-O/-N) 的固有反应性，以实现烷醇胺的化学选择性官能化。已记录了包含为实现氨基醇选择性 O/N 官能化而开发的各种方法的报告的综合汇编。在这篇综述中，我们回顾了近几十年来使用各种合成方法研究的一些发现。为了帮助我们组织和强调这些研究中出现的重要想法，我们集中讨论了所调查的反应的建议机制基础。