Lack of preclinical model translation is often blamed for failed drug development. Here we discuss mouse models within the context of human steatotic liver disease (SLD). Variables such as aging and non-food hepatic stressors are often ignored but could explain challenges in reproducing the human disease in a laboratory.

中文翻译：

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MASLD 在小鼠体内的翻译过程中是否丢失了？


缺乏临床前模型转化常常被指责为药物开发失败的原因。在这里，我们讨论人类脂肪肝病 (SLD) 背景下的小鼠模型。衰老和非食物肝脏应激源等变量经常被忽视，但可以解释在实验室重现人类疾病的挑战。