Nonmuscle-invasive bladder cancer (NMIBC) has high recurrence rates and is often treated with mitomycin C (MMC) and bacillus Calmette-Guérin (BCG). Their efficacy relies on phase 2 enzyme metabolism and immune response activation, respectively. Dietary isothiocyanates, phytochemicals in cruciferous vegetables, are phase 2 enzyme inducers and immunomodulators, and may impact treatment outcomes. We investigated the modifying effects of cruciferous vegetable and isothiocyanate intake on recurrence risk following MMC or BCG treatment.

中文翻译：

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膳食异硫氰酸盐对丝裂霉素 C 和卡介苗治疗非肌层浸润性膀胱癌疗效的影响。


非肌层浸润性膀胱癌 (NMIBC) 复发率很高，通常采用丝裂霉素 C (MMC) 和卡介苗 (BCG) 治疗。它们的功效分别依赖于第二相酶代谢和免疫反应激活。膳食异硫氰酸盐是十字花科蔬菜中的植物化学物质，是第 2 相酶诱导剂和免疫调节剂，可能会影响治疗结果。我们研究了十字花科蔬菜和异硫氰酸盐摄入量对 MMC 或 BCG 治疗后复发风险的影响。