Here, we have successfully achieved the addition of difluoroacetate radicals to 2-aryl-3H-indol-3-ones, enabling various difluoroalkylations of C2-tetrasubstituted 2-aryl indolin-3-ones in a highly efficient and economical manner. It is worth mentioning that these difluoroalkylation compounds can be easily transformed into various derivatives under mild reaction conditions. Control experiments suggest the involvement of ethyl difluoroacetate radical species in the reaction.

中文翻译：

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二氟乙酸基快速掺入2-芳基-3H-吲哚-3-酮合成含氟C2-四取代吲哚啉-3-酮


在这里，我们成功实现了二氟乙酸酯基团与2-芳基-3H-吲哚-3-酮的加成，从而以高效且经济的方式实现了C2-四取代的2-芳基吲哚啉-3-酮的各种二氟烷基化。值得一提的是，这些二氟烷基化化合物在温和的反应条件下可以很容易地转化为各种衍生物。对照实验表明二氟乙酸乙酯自由基物种参与了反应。