In this issue of Molecular Cell, Yi et al.¹ demonstrate that reduced mTORC1 activity induces the CTLH E3 ligase-dependent degradation of HMGCS1, an enzyme in the mevalonate pathway, thus revealing a unique connection between mTORC1 signaling and the degradation of a specific metabolic enzyme via the ubiquitin-proteasome system.

中文翻译：

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mTORC1 在代谢酶降解中的挑剔

在本期《分子细胞》中，Yi 等人。^图1表明，mTORC1活性降低会诱导HMGCS1（甲羟戊酸途径中的一种酶）发生CTLH E3连接酶依赖性降解，从而揭示了mTORC1信号传导与泛素-蛋白酶体系统对特定代谢酶的降解之间的独特联系。