Epithelial folding is a fundamental biological process that requires epithelial interactions with the underlying mesenchyme. In this issue of Cell, Huycke et al. investigate intestinal villus formation. They discover that water-droplet-like behavior of mesenchymal cells drives their coalescence into uniformly patterned aggregates, which generate forces on the epithelium to initiate folding.

中文翻译：

---

关于机械相和形式

上皮折叠是一个基本的生物过程，需要上皮与下面的间质相互作用。在本期《细胞》杂志中，Huycke 等人。研究肠绒毛的形成。他们发现间充质细胞的水滴状行为驱动它们聚结成均匀图案的聚集体，从而在上皮上产生力以启动折叠。