<br>前沿|肉桂醛的药理作用及作用机制研究进展,Frontiers in Pharmacology

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前沿|肉桂醛的药理作用及作用机制研究进展
Frontiers in Pharmacology ( IF 4.4 ) Pub Date : 2024-05-06 , DOI: 10.3389/fphar.2024.1365949
Jiageng Guo _{1,

2,

3} , Shidu Yan _{1,

2,

3} , Xinya Jiang ₄ , Zixia Su _{1,

2,

3} , Fan Zhang _{1,

2,

3} , Jinling Xie _{1,

2,

3} , Erwei Hao _{1,

2,

3,

5} , Chun Yao ₅

Affiliation

肉桂醛是从肉桂和其他物种中提取的，为不同的化学性质和治疗效果提供了多种来源。除了天然提取之外，合成生产和微生物发酵等生物技术方法也提供了可扩展且可持续的替代方案。肉桂醛具有广泛的药理学范围，通过详细的机制影响各种疾病。本综述旨在概括肉桂醛的多种治疗作用、其分子相互作用及其在临床应用中的潜力。这篇综述借鉴了最近的科学研究和 Web of Science、PubMed 和 ScienceDirect 等数据库，概述了肉桂醛在治疗炎症、细菌感染、癌症、糖尿病以及心血管和肾脏疾病方面的功效。它主要通过抑制 NF-κB 通路和调节促炎介质，同时破坏细菌细胞和诱导癌细胞凋亡来发挥作用。该化合物通过改善葡萄糖摄取和胰岛素敏感性来增强代谢健康，并通过其抗炎和降脂作用提供心血管保护。此外，它还能促进肾脏疾病管理中的自噬。临床前和临床研究支持其治疗潜力，强调需要进一步研究其机制和安全性，以开发基于肉桂醛的新药。

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Frontiers | Advances in pharmacological effects and mechanism of action of cinnamaldehyde

Cinnamaldehyde is extracted from Cinnamomum cassia and other species, providing diverse sources for varying chemical properties and therapeutic effects. Besides natural extraction, synthetic production and biotechnological methods like microbial fermentation offer scalable and sustainable alternatives. Cinnamaldehyd demonstrates a broad pharmacological range, impacting various diseases through detailed mechanisms. This review aims to encapsulate the diverse therapeutic effects of cinnamaldehyde, its molecular interactions, and its potential in clinical applications. Drawing on recent scientific studies and databases like Web of Science, PubMed, and ScienceDirect, this review outlines cinnamaldehyde’s efficacy in treating inflammatory conditions, bacterial infections, cancer, diabetes, and cardiovascular and kidney diseases. It primarily operates by inhibiting the NF-κB pathway and modulating pro-inflammatory mediators, alongside disrupting bacterial cells and inducing apoptosis in cancer cells. The compound enhances metabolic health by improving glucose uptake and insulin sensitivity and offers cardiovascular protection through its anti-inflammatory and lipid-lowering effects. Additionally, it promotes autophagy in kidney disease management. Preclinical and clinical research supports its therapeutic potential, underscoring the need for further investigation into its mechanisms and safety to develop new drugs based on cinnamaldehyde.

更新日期：2024-05-06

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