<br>芦笋草药衍生的碳量子点：用于医学诊断的发光探针,Chemistry & Biodiversity

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芦笋草药衍生的碳量子点：用于医学诊断的发光探针
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2024-06-02 , DOI: 10.1002/cbdv.202400891
Nisha Yadav ₁ , Deeksha Mudgal ₁ , Manish Mishra ₂ , Vivek Mishra ₁

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利用天然材料合成高荧光碳量子点（CQD）提供了一种可持续的方法来克服与传统化学前体相关的挑战。在这里，我们报道了从芦笋中提取的新型 S,N-自掺杂 CQD（S,N@CQD）的合成。这些 S,N@CQD 具有 16.7% 的荧光量子产率，展示了它们在医学诊断中的潜力。我们证明了 S,N@CQD 作为发光探针检测浓度范围为 0.0–180.0 μM 的抗病原体药物甲硝唑 (MTZ) 和硝唑尼特 (NTZ) 的功效（检测限 (LOD) 为 0.064 μM））和 0.25–40.0 μM（LOD 为 0.05 μM）。该探针成功用于测定药用样品、真实样品和加标人血浆中的 MTZ 和 NTZ，回收率高达 99.82 % 至 103.03 %。此外，S,N@CQD 作为用于血红蛋白 (Hb) 检测的诊断发光探针在 0-900 nM 浓度范围内表现出卓越的功效，最小可检测度为 9.24 nM，与市售医学实验室诊断测试相当。 S,N@CQD 的环保合成和精确检测限满足必要的分析要求，并有望提高临床环境中的诊断能力。这项研究标志着朝着可持续和高效的基于荧光的医疗诊断迈出了重要一步。

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Asparagus officinalis Herb-Derived Carbon Quantum Dots: Luminescent Probe for Medical Diagnostics

The utilization of natural materials for the synthesis of highly fluorescent carbon quantum dots (CQDs) presents a sustainable approach to overcome the challenges associated with traditional chemical precursors. Here, we report the synthesis of novel S,N-self-doped CQDs (S,N@CQDs) derived from asparagus officinalis herb. These S,N@CQDs exhibit 16.7 % fluorescence quantum yield, demonstrating their potential in medical diagnostics. We demonstrate the efficacy of S,N@CQDs as luminescent probes for the detection of anti-pathogenic medications metronidazole (MTZ) and nitazoxanide (NTZ) over concentration ranges of 0.0–180.0 μM (with a limit of detection (LOD) of 0.064 μM) and 0.25–40.0 μM (LOD of 0.05 μM), respectively. The probes were successfully applied to determine MTZ and NTZ in medicinal samples, real samples, and spiked human plasma, with excellent recovery rates ranging from 99.82 % to 103.03 %. Additionally, S,N@CQDs demonstrate exceptional efficacy as diagnostic luminescent probes for hemoglobin (Hb) detection over a concentration range of 0–900 nM, with a minimal detectability of 9.24 nM, comparable to commercially available medical laboratory diagnostic tests. The eco-friendly synthesis and precise detection limits of S,N@CQDs meet necessary analytical requirements and hold promise for advancing diagnostic capabilities in clinical settings. This research signifies a significant step towards sustainable and efficient fluorescence-based medical diagnostics.

更新日期：2024-06-02

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