In measuring cerebral blood flow (CBF) noninvasively using optical techniques, diffusing-wave spectroscopy is often combined with near-infrared spectroscopy to obtain a reliable blood flow index. Measuring the blood flow index at a determined depth remains the ultimate goal. In this study, we present a simple approach using dual-comb lasers where we simultaneously measure the absorption coefficient (μ_a), the reduced scattering coefficient (μ_s^′), and dynamic properties. This system can also effectively differentiate dynamics from various depths, which is crucial for analyzing multilayer dynamics. For CBF measurements, this capability is particularly valuable as it helps mitigate the influence of the scalp and skull, thereby enhancing the specificity of deep tissue.

中文翻译：

---

使用单腔双梳激光器研究混浊介质中的时间分辨动力学


在使用光学技术无创​​测量脑血流量（CBF）时，扩散波光谱通常与近红外光谱相结合，以获得可靠的血流指标。测量确定深度的血流指数仍然是最终目标。在这项研究中，我们提出了一种使用双梳激光器的简单方法，同时测量吸收系数 (μ _a )、折减散射系数 (μ _s ) 和动态特性。该系统还可以有效区分不同深度的动力学，这对于分析多层动力学至关重要。对于 CBF 测量，这种功能特别有价值，因为它有助于减轻头皮和颅骨的影响，从而增强深层组织的特异性。