ed controlled trial compared the outcomes between acute lower dosage PD (18-24 liters per day) and Intermittent HD (three times per week) from May 2018 to January 2021 in patients with AKI. The primary outcome was 28-day mortality rate. Secondary outcomes included 28-day dialysis-free survival and kidney recovery, metabolic profile, and procedure-related complications. Non-inferiority of PD to HD would be demonstrated if the upper bound of the 95% confidence interval (CI) on risk difference (PD-HD) in 28-day mortality rates between the two groups was less than 20%. Results: We included 157 patients (80 allocated to PD and 77 to intermittent HD). Before kidney replacement therapy initiation, baseline clinical characteristics between groups were comparable. Overall mean age was 57 ± 15 years old. The most frequent cause of AKI was sepsis (68%). There was no difference in 28-day mortality between acute PD and intermittent HD (50 vs 49%, risk difference 0.6 (95% CI -15.0,16.3), and 28-day dialysis-free survival (42% vs 37%, risk difference 4.6 (95% CI -11.1,20.3)). Mean weekly Kt/V urea were 2.11 ± 1.14 and 2.55 ± 1.11 in the PD and intermittent HD groups, respectively. The 7-day fluid balance of PD and intermittent HD patients were not significantly different. There was more frequent intradialytic hypotension in the intermittent HD group and more frequent hypokalemia in the PD group. Conclusions: In this study of patients with AKI, there was no significant difference in 28-day mortality between acute PD and intermittent HD. Copyright © 2024 by the American Society of Nephrology...

中文翻译：

---

急性肾损伤中低剂量急性腹膜透析与急性间歇性血液透析：一项随机对照试验


ed 对照试验比较了 2018 年 5 月至 2021 年 1 月 AKI 患者中急性低剂量 PD（每天 18-24 升）和间歇性 HD（每周 3 次）的结果。主要结局是28天死亡率。次要结局包括 28 天无透析生存率和肾脏恢复、代谢情况以及手术相关并发症。如果两组之间 28 天死亡率的风险差异 (PD-HD) 的 95% 置信区间 (CI) 上限小于 20%，则可以证明 PD 相对于 HD 的非劣效性。结果：我们纳入了 157 名患者（80 名分配给 PD，77 名分配给间歇性 HD）。在开始肾脏替代治疗之前，各组之间的基线临床特征具有可比性。总体平均年龄为 57 ± 15 岁。 AKI 最常见的原因是败血症 (68%)。急性 PD 和间歇性 HD 之间的 28 天死亡率没有差异（50% vs 49%，风险差异 0.6 (95% CI -15.0,16.3），28 天无透析生存率（42% vs 37%，风险PD 和间歇性 HD 组的平均每周 Kt/V 尿素分别为 2.11 ± 1.14 和 2.55 ± 1.11 PD 和间歇性 HD 患者的 7 天液体平衡为 4.6 (95% CI -11.1,20.3)。间歇性 HD 组的透析中低血压更常见，而 PD 组的低钾血症更常见。 结论：在这项针对 AKI 患者的研究中，急性 PD 和间歇性 HD 的 28 天死亡率没有显着差异。 . 版权所有 © 2024 美国肾脏病学会...