SenNet recommendations for detecting senescent cells in different tissues,Nature Reviews Molecular Cell Biology

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SenNet recommendations for detecting senescent cells in different tissues
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2024-06-03 , DOI: 10.1038/s41580-024-00738-8
Vidyani Suryadevara ₁ , Adam D Hudgins ₂ , Adarsh Rajesh ₃ , Alberto Pappalardo ₄ , Alla Karpova ₅ , Amit K Dey ₆ , Ann Hertzel _{7,

8} , Anthony Agudelo _{9,

10} , Azucena Rocha _{9,

10} , Bikem Soygur ₁₁ , Birgit Schilling ₁₁ , Chase M Carver _{12,

13} , Cristina Aguayo-Mazzucato ₁₄ , Darren J Baker _{13,

15} , David A Bernlohr _{7,

8} , Diana Jurk _{12,

13,

16} , Dilyana B Mangarova ₁ , Ellen M Quardokus ₁₇ , Elizabeth Ann L Enninga ₁₈ , Elizabeth L Schmidt _{7,

8} , Feng Chen ₅ , Francesca E Duncan _{11,

19} , Francesco Cambuli ₂₀ , Gagandeep Kaur ₂₁ , George A Kuchel _{22,

23} , Gung Lee _{12,

13} , Heike E Daldrup-Link ₁ , Helene Martini _{12,

13} , Hemali Phatnani _{20,

24} , Iman M Al-Naggar ₂₂ , Irfan Rahman ₂₁ , Jia Nie ₂₅ , João F Passos _{12,

13} , Jonathan C Silverstein ₂₆ , Judith Campisi ₁₁ , Julia Wang ₅ , Kanako Iwasaki ₁₄ , Karina Barbosa ₃ , Kay Metis ₂₆ , Kerem Nernekli ₁ , Laura J Niedernhofer _{7,

8} , Li Ding ₅ , Lichao Wang _{22,

23} , Lisa C Adams ₁ , Liu Ruiyang ₅ , Madison L Doolittle _{12,

13,

27} , Marcos G Teneche ₃ , Marissa J Schafer _{12,

13,

16} , Ming Xu _{22,

23} , Mohammadjavad Hajipour ₁ , Mozhgan Boroumand ₆ , Nathan Basisty ₆ , Nicholas Sloan ₂₈ , Nikolai Slavov _{10,

29,

30,

31} , Olena Kuksenko ₂₈ , Paul Robson _{32,

33} , Paul T Gomez _{12,

13} , Periklis Vasilikos ₃₄ , Peter D Adams ₃ , Priscila Carapeto ₁₄ , Quan Zhu ₃₅ , Ramalakshmi Ramasamy ₃₂ , Rolando Perez-Lorenzo ₄ , Rong Fan ₃₆ , Runze Dong _{37,

38} , Ruth R Montgomery ₃₆ , Sadiya Shaikh ₂₁ , Sanja Vickovic _{20,

39,

40,

41} , Shanshan Yin ₃ , Shoukai Kang ₃₇ , Sonja Suvakov _{12,

42} , Sundeep Khosla _{12,

13,

27} , Vesna D Garovic _{18,

42} , Vilas Menon _{24,

43} , Yanxin Xu _{44,

45,

46} , Yizhe Song ₅ , Yousin Suh _{2,

34} , Zhixun Dou _{44,

45,

46} , Nicola Neretti _{9,

10}

Affiliation

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.
Department of Dermatology, Columbia University, New York, NY, USA.
Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
National Institute on Aging, NIH, Baltimore, MD, USA.
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Center on the Biology of Aging, Brown University, Providence, RI, USA.
The Buck Institute for Research on Aging, Novato, CA, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA.
Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
New York Genome Center, New York, NY, USA.
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.
Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Department of Bioengineering, Northeastern University, Boston, MA, USA.
Department of Biology, Northeastern University, Boston, MA, USA.
Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, MA, USA.
The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Institute for Systems Genomics, University of Connecticut, Farmington, CT, USA.
Department of Genetics and Development, Columbia University, New York, NY, USA.
Center for Epigenomics, University of California, San Diego, CA, USA.
Yale-Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA.
Herbert Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.
Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Beijer Laboratory for Gene and Neuro Research, Uppsala University, Uppsala, Sweden.
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Center for Translational and Computational Neuroimmunology, Columbia University Irving Medical Center, New York, NY, USA.
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest. By contrast, in tissues, these cells are relatively rare and difficult to characterize, and it is now established that fully differentiated, postmitotic cells can also acquire a senescence phenotype. The SenNet Biomarkers Working Group was formed to provide recommendations for the use of cellular senescence markers to identify and characterize senescent cells in tissues. Here, we provide recommendations for detecting senescent cells in different tissues based on a comprehensive analysis of existing literature reporting senescence markers in 14 tissues in mice and humans. We discuss some of the recent advances in detecting and characterizing cellular senescence, including molecular senescence signatures and morphological features, and the use of circulating markers. We aim for this work to be a valuable resource for both seasoned investigators in senescence-related studies and newcomers to the field.

中文翻译：

SenNet 关于检测不同组织中衰老细胞的建议

细胞衰老曾经被认为是组织培养特有的现象，但现在已与各种生物过程联系起来，对人类、啮齿动物和其他物种既有有益的作用，也有有害的作用。我们对衰老细胞生物学的大部分理解仍然源于组织培养研究，其中培养物中的每个细胞都被驱动到不可逆的细胞周期停滞。相比之下，在组织中，这些细胞相对罕见且难以表征，现在已经确定完全分化的有丝分裂后细胞也可以获得衰老表型。 SenNet 生物标记物工作组的成立是为了提供使用细胞衰老标记物来识别和表征组织中衰老细胞的建议。在此，我们基于对报告小鼠和人类 14 种组织衰老标记的现有文献的综合分析，提出了检测不同组织中衰老细胞的建议。我们讨论了检测和表征细胞衰老的一些最新进展，包括分子衰老特征和形态特征，以及循环标记物的使用。我们的目标是让这项工作成为衰老相关研究中经验丰富的研究人员和该领域的新手的宝贵资源。

更新日期：2024-06-03

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