A remote activating strategy enabled (RASE) three-component formal metathesis among an alkyl benzyl ether, an alkyl aryl ether and a Brønsted acid is achieved through metal-free domino activation of two C(sp³)–O bonds in alkyl ethers under mild conditions, leading to dealkoxylative C(sp³)–N coupling products in good to excellent yields. With the use of in situ generated benzyl alkyl ether in this smooth metathesis, this chemistry offers an efficient strategy for direct site-selective introduction of pharmaceutically significant monocyclic thiazol-2(3H)-one scaffolds onto specific benzylic sites. A probable mechanism is also provided based on the results of control experiments and DFT calculations.

中文翻译：

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通过远程激活策略 (RASE) 多米诺骨牌激活烷基醚中的两个 C(sp3)-O 键进行三组分形式复分解


通过两个 C(sp ³ )–O 的无金属多米诺骨牌激活，实现了烷基苄基醚、烷基芳基醚和布朗斯台德酸之间的远程激活策略 (RASE) 三组分形式复分解在温和的条件下，在烷基醚中形成键，产生脱烷氧基化的 C(sp ³ )–N 偶联产物，产率良好至优异。通过在这种顺利的复分解中使用原位生成的苄基烷基醚，该化学提供了一种有效的策略，可以将药学上重要的单环噻唑-2(3H)-one支架直接位点选择性地引入到特定的苄基位点上。根据控制实验和 DFT 计算的结果，还提供了可能的机制。