Cystatin C and the misdiagnosis of CKD in older adults,Nature Reviews Nephrology

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Cystatin C and the misdiagnosis of CKD in older adults
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2024-06-03 , DOI: 10.1038/s41581-024-00852-y
Andrew D Rule ₁ , Richard J Glassock ₂

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The use of cystatin C-inclusive equations will continue to propagate the unnecessary overdiagnosis of chronic kidney disease (CKD) in older people. Cystatin C is less biologically specific for CKD than is serum creatinine, inflates the risks of adverse outcomes compared to measured glomerular filtration rate, and does not establish chronicity at a single time point.

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