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Reversing the charge of lysine by genetic code expansion
Nature Chemistry ( IF 19.2 ) Pub Date : 2024-06-03 , DOI: 10.1038/s41557-024-01536-7
Daniela Danková , Christian A. Olsen

Posttranslational modifications alter the structure and function of proteins. Now, genetic code expansion enables encoding of ε-N-succinyllysine and ε-N-glutaryllysine residues to decipher the effects of these modifications on enzymatic activity, protein–protein interactions and protein–DNA interactions.

中文翻译:


通过遗传密码扩展反转赖氨酸的电荷



翻译后修饰改变蛋白质的结构和功能。现在,遗传密码扩展能够编码 ε-N-琥珀酰赖氨酸和 ε-N-戊二酰赖氨酸残基,从而破译这些修饰对酶活性、蛋白质-蛋白质相互作用和蛋白质-DNA 相互作用的影响。
更新日期:2024-06-03
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