<br>青蒿琥酯通过调节氧化应激、炎症、自噬、细胞凋亡和纤维化发挥器官和组织保护作用：证据和机制综述,Antioxidants

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青蒿琥酯通过调节氧化应激、炎症、自噬、细胞凋亡和纤维化发挥器官和组织保护作用：证据和机制综述
Antioxidants ( IF 6.0 ) Pub Date : 2024-06-03 , DOI: 10.3390/antiox13060686
Mingtao Zhu ₁ , Yu Wang ₁ , Jianwei Han ₁ , Yanping Sun ₁ , Shuang Wang ₁ , Bingyou Yang ₁ , Qiuhong Wang ₂ , Haixue Kuang ₁

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人体由众多同步运作的器官和组织组成，它促进新陈代谢、循环和整体有机功能。因此，我们器官和组织的健康状况极大地影响我们的整体健康。近年来，青蒿琥酯（AS）对心、肝、脑、肺、肾、胃肠道、骨骼等多种器官功能的保护作用研究取得了显着进展。体内和体外研究的结果表明，AS 可能成为防止器官损伤的新守护者。其保护机制主要涉及抑制炎症因子并影响抗纤维化、抗衰老、免疫增强、干细胞调节、细胞凋亡、代谢稳态和自噬特性。此外，AS因其明显的抗氧化活性而引起高度关注，包括激活Nrf2和HO-1信号通路、抑制活性氧的释放以及干扰与氧化应激相关的基因和蛋白质的表达。本文全面综述了近年来AS在减轻各种原因造成的机体损伤和保护器官方面所取得的进展，旨在为AS的进一步深入研究和利用提供参考。

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Artesunate Exerts Organ- and Tissue-Protective Effects by Regulating Oxidative Stress, Inflammation, Autophagy, Apoptosis, and Fibrosis: A Review of Evidence and Mechanisms

The human body comprises numerous organs and tissues operating in synchrony, it facilitates metabolism, circulation, and overall organismal function. Consequently, the well-being of our organs and tissues significantly influences our overall health. In recent years, research on the protective effects of artesunate (AS) on various organ functions, including the heart, liver, brain, lungs, kidneys, gastrointestinal tract, bones, and others has witnessed significant advancements. Findings from in vivo and in vitro studies suggest that AS may emerge as a newfound guardian against organ damage. Its protective mechanisms primarily entail the inhibition of inflammatory factors and affect anti-fibrotic, anti-aging, immune-enhancing, modulation of stem cells, apoptosis, metabolic homeostasis, and autophagy properties. Moreover, AS is attracting a high level of interest because of its obvious antioxidant activities, including the activation of Nrf2 and HO-1 signaling pathways, inhibiting the release of reactive oxygen species, and interfering with the expression of genes and proteins associated with oxidative stress. This review comprehensively outlines the recent strides made by AS in alleviating organismal injuries stemming from various causes and protecting organs, aiming to serve as a reference for further in-depth research and utilization of AS.

更新日期：2024-06-03

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