Obesity is a recognized public health epidemic with a prevalence that continues to increase dramatically in nearly all populations, impeding progress in reducing incidence rates of cardiovascular disease. Over the past decade, obesity science has evolved to improve knowledge of its multifactorial causes, identifying important biological causes and sociological determinants of obesity. Treatments for obesity have also continued to develop, with more evidence-based programs for lifestyle modification, new pharmacotherapies, and robust data to support bariatric surgery. Despite these advancements, there continues to be a substantial gap between the scientific evidence and the implementation of research into clinical practice for effective obesity management. Addressing barriers to obesity science implementation requires adopting feasible methodologies and targeting multiple levels (eg, clinician, community, system, policy) to facilitate the delivery of obesity-targeted therapies and maximize the effectiveness of guideline-driven care to at-need patient populations. This scientific statement (1) describes strategies shown to be effective or promising for enhancing translation and clinical application of obesity-based research; (2) identifies key gaps in the implementation of obesity science into clinical practice; and (3) provides guidance and resources for health care professionals, health care systems, and other stakeholders to promote broader implementation and uptake of obesity science for improved population-level obesity management. In addition, advances in implementation science that hold promise to bridge the know-do gap in obesity prevention and treatment are discussed. Last, this scientific statement highlights implications for health research policy and future research to improve patient care models and optimize the delivery and sustainability of equitable obesity-related care.

中文翻译：

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将肥胖科学应用于临床实践：美国心脏协会的科学声明


肥胖是一种公认​​的公共卫生流行病，其患病率在几乎所有人群中持续急剧增加，阻碍了降低心血管疾病发病率的进展。在过去的十年中，肥胖科学不断发展，以提高对其多因素原因的认识，确定肥胖的重要生物学原因和社会学决定因素。肥胖症的治疗方法也在不断发展，有更多基于证据的生活方式改变计划、新的药物疗法以及支持减肥手术的可靠数据。尽管取得了这些进步，科学证据与有效肥胖管理的临床实践研究的实施之间仍然存在很大差距。解决肥胖科学实施的障碍需要采用可行的方法并针对多个层面（例如临床医生、社区、系统、政策），以促进针对肥胖的治疗的提供，并最大限度地提高对有需要的患者群体的指南驱动的护理的有效性。该科学声明 (1) 描述了被证明对加强肥胖研究的转化和临床应用有效或有前途的策略； (2) 确定肥胖科学在临床实践中的关键差距； (3) 为医疗保健专业人员、医疗保健系统和其他利益相关者提供指导和资源，以促进更广泛地实施和采用肥胖科学，以改善人口水平的肥胖管理。此外，还讨论了有望弥补肥胖预防和治疗方面知识差距的实施科学进展。 最后，这一科学声明强调了对健康研究政策和未来研究的影响，以改善患者护理模式并优化公平肥胖相关护理的提供和可持续性。