is one of the most devastating and invasive insect pests throughout the world. It feeds on numerous solanaceous plant species and has evolved resistance to various types of popular chemical agents. Tetraniliprole is a novel diamide chemical agent that acts as a modulator of the ryanodine receptor, and it has been considered as a promising insecticide against . In this study, we subjected a strain to 17 generations of continuous selection with tetraniliprole in the lab. The resulting tetraniliprole-selected strain (YN-Tet) exhibited a 12.9-fold higher resistance to tetraniliprole compared with a susceptible strain (YN–S), and the realized heritability () was estimated to be 0.1437. The YN-Tet strain exhibited a low level of cross-resistance to chlorantraniliprole and significantly higher cytochrome P450 monooxygenase activity. There was a fitness cost of tetraniliprole resistance in the YN-Tet strain, which had a relative fitness of 0.83 compared with the YN-S strain and a significantly lower fecundity per female. These results enhance our knowledge of the risk and mechanism of tetraniliprole resistance, enabling future optimization of resistance management strategies.

中文翻译：

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番茄蛲虫 Tutaabsoluta 抗四苯甲酰胺的风险评估、交叉抗性、生化机制和适应成本


是世界上最具破坏性和入侵性的害虫之一。它以多种茄科植物为食，并进化出了对各种流行化学制剂的抵抗力。 Tetraniliprole 是一种新型二酰胺化学剂，可作为兰尼丁受体的调节剂，被认为是一种有前途的杀虫剂。在这项研究中，我们在实验室中用四苯甲酰胺对菌株进行了 17 代连续选择。与敏感菌株（YN-S）相比，所得的四苯甲酰胺选择菌株（YN-Tet）对四苯甲酰胺的耐药性高出 12.9 倍，并且实现的遗传力（）估计为 0.1437。 YN-Tet 菌株对氯虫苯甲酰胺表现出低水平的交叉耐药性，并且细胞色素 P450 单加氧酶活性显着较高。 YN-Tet品系存在四苯甲酰胺抗性的适应度成本，与YN-S品系相比，其相对适应度为0.83，并且每只雌性的繁殖力明显较低。这些结果增强了我们对四苯甲酰胺耐药性风险和机制的了解，有助于未来优化耐药性管理策略。