Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology.

中文翻译：

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紫杉醇生物合成和可持续生产的合成生物学


对抗癌化合物紫杉醇生物合成途径的不完全了解阻碍了其通过代谢工程的生产。和其他小组最近的报告描述了紫杉醇生物合成中缺失的步骤，特别是包括氧杂环丁烷环的形成。这些发现将促进通过合成生物学可持续生产紫杉醇。