Alkylresorcinols are important biomarkers for evaluating whole wheat foods. However, their structures encompass a broad spectrum of homologs, making isolating and analyzing individual alkylresorcinol notably challenging. Herein, we synthesized highly selective molecularly imprinted polymers (MIPs) utilizing a facile and cost-effective precipitation polymerization method and 5-heneicosylresorcinol (AR) as the template molecule. Various crucial preparation parameters were systematically optimized, such as different porogens, functional monomers, imprinting ratios, and polymerization time. The polymers were characterized through scanning electron microscopy and Fourier transform infrared spectroscopy, and their adsorption performances were thoroughly evaluated. MIPs exhibited a notably enhanced adsorption capacity compared with that of non-imprinted polymers, reaching an optimal adsorption amount of 71.75 mg·mL and imprinting factor of 2.02. Altogether, the synthesized MIPs showed superior affinity and selectivity for AR, as confirmed by their selective extraction, suggesting their potential applications in the analysis, separation, and monitoring of AR in whole wheat foods.

中文翻译：

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分子印迹聚合物的制备用于全麦面粉中烷基间苯二酚的特异性吸附和选择性提取


烷基间苯二酚是评估全麦食品的重要生物标志物。然而，它们的结构包含广泛的同系物，使得分离和分析单个烷基间苯二酚特别具有挑战性。在此，我们利用简便且经济高效的沉淀聚合方法和 5-二十二烷基间苯二酚（AR）作为模板分子合成了高选择性分子印迹聚合物（MIP）。系统优化了各种关键的制备参数，例如不同的致孔剂、功能单体、印迹比例和聚合时间。通过扫描电子显微镜和傅里叶变换红外光谱对聚合物进行了表征，并对其吸附性能进行了全面评估。与非印迹聚合物相比，MIPs的吸附容量显着增强，最佳吸附量为71.75 mg·mL，印迹因子为2.02。总而言之，合成的 MIP 对 AR 表现出优异的亲和力和选择性，正如其选择性提取所证实的那样，这表明它们在全麦食品中 AR 的分析、分离和监测方面具有潜在的应用前景。