Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis,Ultrasonics Sonochemistry

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Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis
Ultrasonics Sonochemistry ( IF 8.7 ) Pub Date : 2024-05-27 , DOI: 10.1016/j.ultsonch.2024.106928
Lin Wu ₁ , Kai Zhao ₂ , Leyuan Xu ₃ , Junming Cui ₂ , Li Ruan ₂ , Shifang Bei ₄ , Jin Cao ₃ , Xueyong Qi ₃ , Song Shen ₃

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Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by infiltration of inflammatory cells, hyperplasia of synovium, and destruction of the joint cartilage. Owing to the low drug delivery efficiency and limited immunosuppression effect, complete cure for RA remains a formidable challenge. Here, we show that live macrophages (Mφs) carrying protoporphyrin-loaded FeO nanoparticles can migrate to the RA tissues and inhibit the inflammation by sonodynamic therapy. The inflammation of RA leads to the release of cytokines, which guides the migration of the Mφs into the RA tissues, realizing precise delivery of therapeutics. The following sonodynamic therapy induced by ultrasound and protoporphyrin destructs the proliferating synovial cells and also infiltrated inflammatory cells, demonstrating significant therapeutic effect for RA. Meanwhile, the cytokines and relapse of RA can be remarkably suppressed because of the efficient damage to the resident inflammatory cells.

中文翻译：

巨噬细胞介导的原卟啉递送用于类风湿性关节炎的声动力治疗

类风湿性关节炎（RA）是一种慢性全身炎症性疾病，其特征为炎症细胞浸润、滑膜增生和关节软骨破坏。由于药物输送效率低和免疫抑制效果有限，彻底治愈RA仍然是一个艰巨的挑战。在这里，我们发现携带原卟啉 Fe3O 纳米颗粒的活巨噬细胞（Mφs）可以迁移到 RA 组织并通过声动力疗法抑制炎症。 RA的炎症导致细胞因子的释放，引导Mφ迁移到RA组织中，实现治疗的精准递送。随后由超声和原卟啉诱导的声动力治疗破坏了增殖的滑膜细胞和浸润的炎症细胞，显示出对 RA 的显着治疗效果。同时，由于对常驻炎症细胞的有效破坏，可以显着抑制细胞因子和RA的复发。

更新日期：2024-05-27

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