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Stiff tumours exhaust T cells
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-05-31 , DOI: 10.1038/s41577-024-01053-1 Lucy Bird
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-05-31 , DOI: 10.1038/s41577-024-01053-1 Lucy Bird
CD8+ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through the transcription factor OSR2.
中文翻译:
坚硬的肿瘤会耗尽 T 细胞
由于通过转录因子 OSR2 发出信号,当暴露于坚硬实体瘤的机械力时,CD8+ T 细胞会变得疲惫不堪。
更新日期:2024-05-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
坚硬的肿瘤会耗尽 T 细胞
由于通过转录因子 OSR2 发出信号,当暴露于坚硬实体瘤的机械力时,CD8+ T 细胞会变得疲惫不堪。