We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. We used this platform to generate antibody–peptide inhibitor conjugates (APICs) that target a family of proteases, the cysteine cathepsins. Our drug design and targeted delivery approach ensure specific inhibition and achieve therapeutic efficacy in different cancer cells and osteoclasts.

中文翻译：

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用于靶向抑制半胱氨酸蛋白酶的抗体-肽缀合物


我们开发了一种合理的方法来设计基于肽的共价抑制剂，并将抑制剂与抗体偶联以进行细胞特异性递送。我们利用这个平台生成了针对半胱氨酸组织蛋白酶家族的抗体-肽抑制剂缀合物（APIC）。我们的药物设计和靶向递送方法确保对不同的癌细胞和破骨细胞进行特异性抑制并达到治疗效果。