Unfolding emergency calls stress granules to the ER,Nature Cell Biology

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Unfolding emergency calls stress granules to the ER
Nature Cell Biology ( IF 17.3 ) Pub Date : 2024-05-31 , DOI: 10.1038/s41556-024-01434-7
David Pincus ₁ , Scott A Oakes ₂

Affiliation

Sensing stress within the endoplasmic reticulum (ER), the ER transmembrane protein IRE1α initiates a signal transduction pathway to restore homeostasis. A study finds that this process requires an ER membrane-bound phase separation event that leads to the local assembly of stress granules (SGs) and delivery of signalling components.

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