The majority of the human non-coding genome remains poorly studied. A user-friendly genome-wide screening system composed of thousands of paired single-guide RNAs for the deletion of non-coding regions revealed key functions of many non-coding elements in cell growth and cell differentiation and in cellular response to drugs.

中文翻译：

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用于大规模研究非编码基因组功能的配对 CRISPR 筛选文库


大多数人类非编码基因组的研究仍然很少。用户友好的全基因组筛选系统由数千个配对的单向导RNA组成，用于删除非编码区域，揭示了许多非编码元件在细胞生长和细胞分化以及细胞对药物反应中的关键功能。