Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study,European Journal of Epidemiology

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Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study
European Journal of Epidemiology ( IF 7.7 ) Pub Date : 2024-05-30 , DOI: 10.1007/s10654-024-01123-7
Liza M Y Gelissen ₁ , Robin van den Bergh ₁ , Amir H Talebi ₁ , Angelika D Geerlings ₁ , Bart R Maas ₁ , Myrthe M Burgler ₁ , Yvet Kroeze ₁ , Agnes Smink ₁ , Bastiaan R Bloem ₁ , Marten Munneke ₁ , Yoav Ben-Shlomo ₂ , Sirwan K L Darweesh ₁

Affiliation

Introduction

The PRIME-NL study prospectively evaluates a new integrated and personalized care model for people with parkinsonism, including Parkinson’s disease, in a selected region (PRIME) in the Netherlands. We address the generalizability and sources of selection and confounding bias of the PRIME-NL study by examining baseline and 1-year compliance data.

Methods

First, we assessed regional baseline differences between the PRIME and the usual care (UC) region using healthcare claims data of almost all people with Parkinson’s disease in the Netherlands (the source population). Second, we compared our questionnaire sample to the source population to determine generalizability. Third, we investigated sources of bias by comparing the PRIME and UC questionnaire sample on baseline characteristics and 1-year compliance.

Results

Baseline characteristics were similar in the PRIME (n = 1430) and UC (n = 26,250) source populations. The combined questionnaire sample (n = 920) was somewhat younger and had a slightly longer disease duration than the combined source population. Compared to the questionnaire sample in the PRIME region, the UC questionnaire sample was slightly younger, had better cognition, had a longer disease duration, had a higher educational attainment and consumed more alcohol. 1-year compliance of the questionnaire sample was higher in the UC region (96%) than in the PRIME region (92%).

Conclusion

The generalizability of the PRIME-NL study seems to be good, yet we found evidence of some selection bias. This selection bias necessitates the use of advanced statistical methods for the final evaluation of PRIME-NL, such as inverse probability weighting or propensity score matching. The PRIME-NL study provides a unique window into the validity of a large-scale care evaluation for people with a chronic disease, in this case parkinsonism.

中文翻译：

评估帕金森病护理评估的有效性：PRIME-NL 研究

介绍

PRIME-NL 研究前瞻性地评估了荷兰选定地区 (PRIME) 为帕金森症患者（包括帕金森病）提供的一种新的综合个性化护理模式。我们通过检查基线和 1 年合规性数据来解决 PRIME-NL 研究的普遍性、选择来源和混杂偏差。

方法

首先，我们使用荷兰几乎所有帕金森病患者（源人群）的医疗保健索赔数据评估了 PRIME 和常规护理 (UC) 区域之间的区域基线差异。其次，我们将调查问卷样本与源人群进行比较，以确定普遍性。第三，我们通过比较 PRIME 和 UC 问卷样本的基线特征和 1 年依从性来调查偏差来源。

结果

PRIME (n = 1430) 和 UC (n = 26,250) 来源人群的基线特征相似。合并的问卷样本 (n = 920) 比合并的来源人群更年轻，病程也稍长。与PRIME地区的问卷样本相比，UC问卷样本年龄稍小，认知能力较好，病程较长，受教育程度较高，饮酒量较多。 UC 地区问卷样本的 1 年依从性 (96%) 高于 PRIME 地区 (92%)。