To compare the ganglion cell complex (GCC) thickness in eyes with age-related macular degeneration (AMD) vs healthy controls in an elderly Amish population. Prospective cross-sectional study. This is a post hoc analysis of the family-based prospective study of Amish subjects. Study subjects underwent imaging with the Cirrus HD-OCT (Carl Zeiss Meditec Inc) using a macular cube protocol of 512 × 128 scans (128 horizontal B-scans, each comprising 512 A-scans) over a 6 mm × 6 mm region centered on the fovea. The ganglion cell analysis algorithm calculated the GCC thickness by segmenting the outer boundaries of the retinal nerve fiber layer (RNFL) and inner plexiform layer (IPL) in all B-scans of the volume, with the region between these boundaries representing the combined thickness of the ganglion cell layer (GCL) and the IPL. A number of parameters were used to evaluate the GCC thickness: the average GCC thickness, minimum (lowest GCC thickness at a single meridian crossing the elliptical annulus), and sectoral (within each of 6 sectoral areas: superior, superotemporal, superonasal, inferior, inferonasal, and inferotemporal). The stage of AMD was graded on color fundus photographs in accordance with the Beckman Initiative for Macular Research classification system. The GCC thickness in AMD eyes is reduced compared to normal eyes; however, the relationship is complex, with the greatest reduction in late AMD eyes (particularly eyes with GA) but no difference between early and intermediate AMD eyes.

中文翻译：

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年龄相关性黄斑变性中神经节细胞复合体的改变：阿米什眼科研究分析


比较老年阿米什人群中患有年龄相关性黄斑变性 (AMD) 的眼睛与健康对照眼睛的神经节细胞复合体 (GCC) 厚度。前瞻性横断面研究。这是对阿米什受试者基于家庭的前瞻性研究的事后分析。研究对象使用 Cirrus HD-OCT (Carl Zeiss Meditec Inc) 进行成像，使用黄斑立方协议在以中央凹。神经节细胞分析算法通过分割体积的所有 B 扫描中的视网膜神经纤维层 (RNFL) 和内丛状层 (IPL) 的外边界来计算 GCC 厚度，这些边界之间的区域代表神经节细胞层 (GCL) 和 IPL。使用许多参数来评估 GCC 厚度：平均 GCC 厚度、最小值（穿过椭圆环的单个子午线处的最低 GCC 厚度）和扇形区域（在 6 个扇形区域中的每一个区域内：上、颞上、鼻上、下、鼻下和颞下）。根据贝克曼黄斑研究计划分类系统，根据彩色眼底照片对 AMD 的阶段进行分级。 AMD眼的GCC厚度较正常眼减少；然而，这种关系很复杂，晚期 AMD 眼睛（尤其是 GA 眼睛）的减少幅度最大，但早期和中期 AMD 眼睛之间没有差异。