Albiflorin, a principal monoterpene glycoside isolated from Pall., is known for its extensive pharmacological properties and medicinal value in a number of traditional Chinese medicine recipes. Herein, we consolidate current research on the biological profile, anti-inflammatory capabilities, pharmacokinetics, tissue distribution, and toxicity of albiflorin with the, aim of delineating its therapeutic potential and safety profile. Albiflorin exhibits remarkable anti-inflammatory effects in various disease models, including respiratory, urinary, gastrointestinal, and rheumatic conditions, as well as metabolic and nutritional diseases, blood system disorders, mental illnesses, and pain. Pharmacokinetic studies have revealed its efficient absorption, distribution, and elimination, indicating favorable bioavailability with minimal toxicity, as supported by traditional toxicity assessments and next-generation metabolomics analyses. Despite its proven efficacy in a broad spectrum of health conditions, comprehensive toxicological studies are scarce, highlighting the need for further research to ascertain its safety in clinical applications. This review underscores the significant therapeutic promise of albiflorin, rooted in its efficacy as the key active ingredient in relevant traditional Chinese medicine formulas and reinforced by modern scientific inquiry. Albiflorin stands at the intersection of historical wisdom and contemporary pharmacological research, warranting further exploration to harness its full medical potential, especially for the treatment of inflammation-related diseases.

中文翻译：

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白花素的起源、抗炎作用、机制、药代动力学和毒性的系统综述


Albiflorin 是从 Pall. 中分离出来的一种主要单萜糖苷，以其广泛的药理特性和在许多中药配方中的药用价值而闻名。在此，我们整合了目前对白花素的生物学特征、抗炎能力、药代动力学、组织分布和毒性的研究，旨在描绘其治疗潜力和安全性。 Albiflorin 在多种疾病模型中表现出显着的抗炎作用，包括呼吸系统、泌尿系统、胃肠道和风湿性疾病，以及代谢和营养疾病、血液系统疾病、精神疾病和疼痛。药代动力学研究揭示了其有效的吸收、分布和消除，表明其具有良好的生物利用度和最小的毒性，这得到了传统毒性评估和下一代代谢组学分析的支持。尽管其在广泛的健康状况下已被证明有效，但全面的毒理学研究却很少，这突出表明需要进一步研究以确定其在临床应用中的安全性。本综述强调了白花素的重要治疗前景，其根源在于其作为相关中药配方中关键活性成分的功效，并通过现代科学探究得到强化。 Albiflorin 处于历史智慧和当代药理学研究的交汇点，值得进一步探索以充分利用其医学潜力，特别是在治疗炎症相关疾病方面。