Rediscovering citrate as a biomarker for prostate cancer,Nature Reviews Urology

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Rediscovering citrate as a biomarker for prostate cancer
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2024-05-29 , DOI: 10.1038/s41585-024-00899-3
Lucas Galey _{1,

2,

3} , Ayokunle Olanrewaju _{4,

5} , Hermann Nabi _{3,

6,

7} , Jean-Sébastien Paquette _{8,

9,

10} , Frédéric Pouliot _{3,

6,

11} , Étienne Audet-Walsh _{1,

2,

3}

Affiliation

Endocrinology-Nephrology Research Axis, Centre de recherche du CHU de Québec, Université Laval, Québec City, Québec, Canada.
Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec City, Québec, Canada.
Centre de recherche sur le cancer de l'Université Laval, Québec City, Québec, Canada.
Department of Mechanical Engineering, University of Washington, Seattle, WA, USA.
Department of Bioengineering, University of Washington, Seattle, WA, USA.
Oncology Axis, Centre de recherche du CHU de Québec, Université Laval, Québec City, Québec, Canada.
Departement of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec City, Québec, Canada.
Laboratoire de recherche et d'innovation en médecine de première ligne (ARIMED), Groupe de médecine de famille universitaire de Saint-Charles-Borromée, CISSS Lanaudière, Saint-Charles-Borromée, Québec, Canada.
VITAM Research Centre for Sustainable Health, Québec City, Québec, Canada.
Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Québec City, Québec, Canada.
Department of Surgery, Faculty of Medicine, Université Laval, Québec City, Québec, Canada.

For many years, PSA has been the most commonly used biomarker for prostate cancer screening and diagnosis. Although serum PSA measurement is highly sensitive, this biomarker has several limitations. Citrate, a molecule closely linked to the unique metabolism of prostate cancer, has the potential to be used as a complementary biomarker alongside PSA.

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