AimTo investigate the effects of high‐intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes.Materials and MethodsForty‐eight Wistar rats were divided into four groups: non‐trained (NT); non‐trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural tests were conducted to assess anxiety and memory. Post euthanasia, we evaluated the systemic inflammatory profile and oxidative stress markers in the hippocampus and amygdala. A morphological evaluation and elemental composition analysis of the mandibular alveolar bone were performed.ResultsPD exacerbated alveolar bone level, bone surface damage and alterations in calcium and phosphorus percentages on the bone surface (p < .05), while HIIT attenuated these changes (p < .05). HIIT improved systemic inflammatory markers altered by PD (tumour necrosis factor [TNF]‐α, interleukin [IL]‐10, TNF‐α/IL‐10 and IL‐1β/IL‐10 ratios, p < .05). PD animals exhibited lower total antioxidant capacity and levels of thiobarbituric acid reactive substances in the amygdala and hippocampus, respectively (p < .05). HIIT maintained these parameters at levels similar to those in NT animals. HIIT improved anxiety and memory outcomes altered by PD (p < .05).ConclusionsHIIT attenuates systemic inflammation, anxiety and memory outcomes promoted by PD.

中文翻译：

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高强度间歇训练可减轻牙周炎的进展并改善大鼠的行为方面


目的探讨高强度间歇训练 （HIIT） 对牙周炎 （PD） 进展和行为结局的影响。材料和方法将 48 只 Wistar 大鼠分为 4 组：未经训练 （NT）;未经 PD 训练;HIIT 伴 PD;和 HIIT。HIIT 方案涉及每日跑步机训练，为期 8 周，第 6 周后通过结扎诱导 PD。进行行为测试以评估焦虑和记忆。安乐死后，我们评估了海马体和杏仁核的全身炎症特征和氧化应激标志物。对下颌牙槽骨进行了形态学评估和元素组成分析。结果PD 加剧了牙槽骨水平、骨表面损伤和骨表面钙磷百分比的变化 （p < .05），而 HIIT 减轻了这些变化 （p < .05）。HIIT 改善了 PD 改变的全身炎症标志物 （肿瘤坏死因子 [TNF]-α、白细胞介素 [IL]-10、TNF-α/IL-10 和 IL-1β/IL-10 比率，p < .05）。PD 动物在杏仁核和海马体中分别表现出较低的总抗氧化能力和硫代巴比妥酸反应物质水平 （p < .05）。HIIT 将这些参数维持在与 NT 动物相似的水平。HIIT 改善了 PD 改变的焦虑和记忆结果 （p < .05）。结论HIIT 减轻 PD 促进的全身炎症、焦虑和记忆结局。