AimThis prospective cohort study investigated the association between periodontal diseases (PDs) and all‐cause and cause‐specific mortality.Materials and MethodsWe utilized adult participants recruited from six National Health and Nutrition Examination Survey cycles (1999–2014) and linked mortality data from the National Death Index up to December 2019. Baseline clinical periodontal examinations were performed by trained and calibrated examiners. All‐cause and cause‐specific mortality was modelled through multivariable Cox proportional hazards and Fine–Gray models to account for competing risks. All models were adjusted for demographic and lifestyle variables, clinical measurements and comorbidities.ResultsOverall, 15,030 participants were included, with a median length of follow‐up of 9 years. Risk of all‐cause mortality was 22% greater in people with PD than the control group (adjusted hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.12–1.31). Risks of mortality by cardiovascular diseases (CVD), respiratory disease and diabetes were highest in participants with severe PD (CVD—sub‐distribution HR [SHR]: 1.38, 95% CI: 1.16–1.64; respiratory—SHR: 1.62, 95% CI: 1.07–2.45; diabetes—SHR: 1.68, 95% CI: 1.12–2.53).ConclusionsSevere PD is associated with all‐cause and cause‐specific mortality among US adults after multivariable adjustment.

中文翻译：

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美国牙周病成人的全因和原因特异性死亡率： 一项前瞻性队列研究


目的这项前瞻性队列研究调查了牙周病 （PDs） 与全因和原因特异性死亡率之间的关联。材料和方法我们利用了从六个全国健康和营养检查周期 （1999-2014） 中招募的成年参与者，并关联了截至 2019 年 12 月的全国死亡指数的死亡率数据。基线临床牙周检查由经过培训和校准的检查员进行。通过多变量 Cox 比例风险和 Fine-Gray 模型对全因死亡率和特定原因死亡率进行建模，以考虑竞争风险。所有模型都根据人口统计学和生活方式变量、临床测量和合并症进行了调整。结果总体而言，共纳入 15,030 名参与者，中位随访时间为 9 年。PD 患者的全因死亡风险比对照组高 22%（调整后的风险比 [HR]：1.22,95% 置信区间 [CI]：1.12-1.31）。严重 PD 参与者死于心血管疾病 （CVD）、呼吸系统疾病和糖尿病的风险最高（CVD—子分布 HR [SHR]：1.38,95% CI：1.16–1.64;呼吸系统—SHR：1.62,95% CI：1.07–2.45;糖尿病—SHR：1.68,95% CI：1.12–2.53）。结论重度 PD 与多变量调整后美国成年人的全因和原因特异性死亡率相关。