Sprayable adhesive glycopolymer hydrogels with rapid in-situ gelation,Polymer Chemistry

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Sprayable adhesive glycopolymer hydrogels with rapid in-situ gelation
Polymer Chemistry ( IF 4.1 ) Pub Date : 2024-05-29 , DOI: 10.1039/d4py00368c
Xianjun Wang ₁ , Hannah G. Abernathy ₁ , Lisa K. Kemp ₁ , Sarah E. Morgan ₁

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Designing a sprayable, shear-thinning hydrogel with rapid in situ gelation opens new opportunities for biomedical applications. Most traditional sprayable hydrogels require time-of-application mixing of reactive solutions, and they face inevitable material loss during application due to their slow gelation kinetics. In this study, we introduce a novel physically crosslinked hydrogel containing saccharide pendant groups characterized by a significant degree of shear-thinning behavior and fast modulus recovery under substantial shear deformation. This hydrogel can be sprayed easily via a commercially available atomizer, and the sprayed gel adheres to a vertically aligned polystyrene Petri dish without dripping or flowing. The incorporation of sugar moieties not only contributes to maintaining the integrity of the gel network, but also facilitates dye penetration and enhances adhesive properties. By evaluating these interdependencies, this research demonstrates the intricate connections between polymer structural features, hydrogel properties, and processing as a sprayable material.

中文翻译：

具有快速原位凝胶化功能的可喷涂粘性糖聚合物水凝胶

设计一种具有快速原位凝胶化功能的可喷雾、剪切稀化水凝胶，为生物医学应用开辟了新的机会。大多数传统的可喷雾水凝胶需要在施用时混合反应溶液，并且由于其缓慢的凝胶化动力学，它们在施用过程中面临不可避免的材料损失。在这项研究中，我们介绍了一种新型物理交联水凝胶，其含有糖侧基，其特征是在大量剪切变形下具有显着程度的剪切稀化行为和快速模量恢复。这种水凝胶可以通过市售雾化器轻松喷涂，并且喷涂的凝胶粘附在垂直排列的聚苯乙烯培养皿上，不会滴落或流动。糖部分的掺入不仅有助于保持凝胶网络的完整性，而且有利于染料渗透并增强粘合性能。通过评估这些相互依赖性，本研究证明了聚合物结构特征、水凝胶特性和可喷涂材料加工之间的复杂联系。

更新日期：2024-05-29

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