Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Academician N. Kipshidze University Clinic - Republican Hospital; IVANE BERITASHVILI CENTER OF EXPERIMENTAL BIOMEDICINE, Department of rheology and diagnostic analytical services. Introduction Despite all biomedical efforts, the prevalence of atrial fibrillation and its associated morbidity and mortality are increasing globally year after year. The disease's unfavorable epidemiological picture determined the reality of the project. There are many hypotheses to explain the pathogenesis of atrial fibrillation. All the hypotheses are based on mechanisms at local points and microwaves (in whole or in part). None of them consider the role of hemodynamics and hemorheology in the formation and progression of atrial fibrillation. It is also unknown how atrial fibrillation affects intracardiac macro- and microcirculation. Purpose The goals of this project were to determine how hemodynamics and hemorheology change in patients with atrial fibrillation. In order to gain a better understanding of the pathological processes underlying AF, we sought to access the relationships between hemodynamics, rheological properties,and the coagulation system of blood. Methods The Erythrocyte (RBC) Aggregation Index (EAI) was monitored in the development and validation cohorts (90 patients and 20 healthy individuals) using the textural analysis system (Tas-Plus, Leitz, Germany) and an innovative "Georgian technique" with the unique function of a quantitative assessment of the EAI. The method was developed by Georgian scientists and is well-known around the world for being direct, numerical, and precise. In all patients Coagulogram and 12-lead standard ECG were performed. Results According to the data obtained, the patients' rheological and coagulation system conditions are the same, and they are distinct from the control group. During the statistical processing of the total amount of fibrinogen (Fib), the patients were divided into three categories. The average Fib in Category I patients was 336.40 ±27,77 mg/dl, and the average EAI-RBC value was 32.8± 9.4. Category II: FIB: 373.00±22.65mg/dl; EAI-RBC: 39.8±13.8 and Category III: FIB:471.27±21.58 mg/dl; EAI-RBC: 42.6±10.4. The control group: FIB: 301±18,1 mg/dl, EAI-RBC: 25.6±1.29. Fibrinogen and the Index of Erythrocyte Aggregation were found to have a linear relationship. The higher the concentration of fibrinogen, the more severe the hemorheological disorders. It should be noted that the categories were chosen without taking into account the forms of atrial fibrillation. Conclusions The findings clearly show the existence of two parallel mechanisms in the body. These are the coagulation systems, characterized by dynamic equilibrium, and the rheology systems, which lack a physiologically balanced opposing system. Coagulation control does not accurately describe hemorheological parameters, which are one of the most powerful mechanisms for atrial fibrillation formation In order to better understand the diseases' occurrence and progression, the simultaneous studies of fibrinogen concentration and rheological parameters are especially important for both fundamental and practical medicine.

中文翻译：

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心房颤动期间的红细胞聚集性和纤维蛋白原


资金致谢 资金来源类型：公共机构。主要资金来源：N. Kipshidze 院士大学诊所 - 共和医院； IVANE BERITASHVILI 实验生物医学中心，流变学和诊断分析服务部。简介 尽管做出了各种生物医学努力，心房颤动的患病率及其相关的发病率和死亡率在全球范围内逐年增加。该疾病不利的流行病学状况决定了该项目的现实性。有许多假说可以解释心房颤动的发病机制。所有假设均基于局部点和微波（全部或部分）的机制。他们都没有考虑血流动力学和血液流变学在心房颤动的形成和进展中的作用。目前还不清楚心房颤动如何影响心内宏观和微循环。目的 该项目的目标是确定房颤患者的血流动力学和血液流变学如何变化。为了更好地了解 AF 的病理过程，我们试图了解血流动力学、流变特性和血液凝固系统之间的关系。方法 使用结构分析系统（Tas-Plus，Leitz，德国）和创新的“格鲁吉亚技术”，在开发和验证队列（90 名患者和 20 名健康个体）中监测红细胞 (RBC) 聚集指数 (EAI)。独特的EAI定量评估功能。该方法由格鲁吉亚科学家开发，以其直接、数值和精确而闻名于世。对所有患者进行凝血图和 12 导联标准心电图检查。 结果根据获得的数据，患者的流变学和凝血系统状况相同，与对照组不同。在纤维蛋白原（Fib）总量的统计处理过程中，将患者分为三类。 I 类患者的平均 Fib 为 336.40 ±27.77 mg/dl，平均 EAI-RBC 值为 32.8± 9.4。 II类：FIB：373.00±22.65mg/dl； EAI-RBC：39.8±13.8 和 III 类：FIB：471.27±21.58 mg/dl； EAI-红细胞：42.6±10.4。对照组：FIB：301±18.1 mg/dl，EAI-RBC：25.6±1.29。发现纤维蛋白原和红细胞聚集指数具有线性关系。纤维蛋白原浓度越高，血液流变学紊乱越严重。应该指出的是，选择类​​别时没有考虑心房颤动的形式。结论 研究结果清楚地表明体内存在两种平行机制。这些是以动态平衡为特征的凝固系统和缺乏生理平衡的对立系统的流变系统。凝血控制并不能准确描述血液流变学参数，而血液流变学参数是心房颤动形成的最有力机制之一。为了更好地了解疾病的发生和进展，纤维蛋白原浓度和流变学参数的同时研究对于基础和实践尤为重要。药品。