Dental, oral, and craniofacial diseases jeopardize health and reduce the quality of life. Accessing disease-related signals in advance is beneficial to prevent the occurrence or progression of those diseases. However, the inconvenience of periodical in-hospital examinations and the difficulty of sustaining daily health monitoring challenge personal compliance and possibly lead to limited prevention or treatment. Medical flexible electronics are electric devices fabricated on soft and extensible substrates to fit the human skin and enable non-invasive continuous monitoring of biophysical/biochemical signals. They provide the possibility of long-term, continuous, comfortable, and wireless healthcare monitoring and are expected to alleviate time and economic consumption by avoiding in-hospital examinations and treatment. Therefore, flexible electronics have emerged for early diagnosis and disease monitoring in stomatology. It is noteworthy that special biophysical/biochemical characteristics and the environment of dental, oral, and craniofacial areas bring distinct challenges that flexible electronics need to address ingeniously to ensure their stability, selectivity, and sensitivity. This review summaries flexible electronics and their specificity when used in dental, oral, and craniofacial applications, including monitoring saliva or cavity-gas related biosignals, sensing the mechanical fluctuation from facial muscle/respiratory activities or orthodontic forces, and executing special functions in the prevention or postoperative recovery of relevant diseases. Furthermore, after analyzing current challenges and proposing potential solutions, the “5I” principles of imperceptibility, intelligence, individualization, integration, and inexpensiveness are presented to help guide the future development of flexible electronics and promote their commercialization for dental, oral, and craniofacial medicine.

牙齿、口腔和颅面疾病危害健康并降低生活质量。提前获取疾病相关信号有利于预防这些疾病的发生或进展。然而，定期住院检查的不便和维持日常健康监测的困难对个人依从性提出了挑战，并可能导致预防或治疗有限。医用柔性电子产品是在柔软且可延展的基材上制造的电子设备，适合人体皮肤，并能够对生物物理/生化信号进行非侵入性连续监测。它们提供了长期、连续、舒适和无线医疗保健监测的可能性，并有望通过避免住院检查和治疗来减少时间和经济消耗。因此，柔性电子器件应运而生，用于口腔医学的早期诊断和疾病监测。值得注意的是，特殊的生物物理/生化特性以及牙齿、口腔和颅面部区域的环境给柔性电子产品带来了独特的挑战，需要巧妙地解决这些挑战，以确保其稳定性、选择性和灵敏度。本综述总结了柔性电子器件及其在牙科、口腔和颅面应用中的特殊性，包括监测唾液或腔体气体相关的生物信号，感测面部肌肉/呼吸活动或正畸力的机械波动，以及在预防中执行特殊功能或相关疾病术后恢复。 此外，在分析当前挑战并提出潜在解决方案后，提出了不可感知、智能、个性化、集成和廉价的“5I”原则，以帮助指导柔性电子的未来发展，并促进其在牙科、口腔和颅面医学领域的商业化。