Light therapies have been applied to millions of patients for treating many kinds of diseases, especially superficial ones. Currently, mainstream light therapies utilize the combined effects of photosensitizers and light to either remove disordered tissue or promote the growth of healthy tissue. Adverse effects of light therapy, including metabolic burden caused by circulatory photosensitizer and skin damage induced by high irradiance light, are yet to be addressed. This study provides a Miniaturized all-in-one Light therapy Device (MiLD). All components required for light therapy, including dual-function microneedles, LED array, control circuit, and battery are integrated together to form a miniaturized portable device with 2 cm in length, 1.7 cm in width, 1.2 cm in height, and 3.6 g in weight. The all-in-one design and patch-to-cure operation of MiLD enables the successful demonstration of point-of-care light therapy. Satisfactory therapeutic effects have been verified in mice on both types of light therapy. Meanwhile, transdermally co-delivering both photosensitizer and light in situ fully avoids photosensitizer accumulation in blood and remarkably reduces the irradiance of light, therefore significantly alleviating metabolic burden and light-induced skin damage. Overall, the MiLD lays the technical foundation of point-of-care light therapy with its miniaturized all-in-one design, simple patch-to-cure operation, satisfactory therapeutic effects, and minimum adverse effects.

光疗法已应用于数百万患者，用于治疗多种疾病，尤其是浅表疾病。目前，主流光疗法利用光敏剂和光的综合作用来去除病变组织或促进健康组织的生长。光疗法的副作用，包括循环光敏剂引起的代谢负担和高辐照度光引起的皮肤损伤，尚未得到解决。本研究提供了一种小型化一体式光疗设备（MiLD）。光疗所需的所有组件，包括双功能微针、LED阵列、控制电路和电池集成在一起，形成长2厘米、宽1.7厘米、高1.2厘米、重3.6克的小型便携式设备重量。 MiLD 的一体化设计和贴片治愈操作使护理点光疗得以成功演示。两种类型的光疗法均已在小鼠身上验证了令人满意的治疗效果。同时，光敏剂和光原位透皮共传递，充分避免了光敏剂在血液中的积累，并显着降低了光的辐照度，从而显着减轻了代谢负担和光引起的皮肤损伤。总体而言，MiLD以其小型化一体式设计、简单的贴片治疗操作、令人满意的治疗效果和最小的不良反应，奠定了即时光疗的技术基础。