An analysis of somatic mutations in blood exomes from 200,618 individuals revealed previously unrecognized genes driving clonal hematopoiesis. Mutations in these genes showed age-dependent clonal expansion and their presence correlated with heightened risks of infection, death and hematological malignancy.

中文翻译：

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血液中新的体细胞突变驱动与年龄相关的克隆造血


对 200,618 名个体血液外显子组体细胞突变的分析揭示了以前未被识别的驱动克隆造血的基因。这些基因的突变显示出年龄依赖性克隆扩张，它们的存在与感染、死亡和血液恶性肿瘤风险增加相关。