4D-Printed MXene-Based Artificial Nerve Guidance Conduit for Enhanced Regeneration of Peripheral Nerve Injuries,Advanced Healthcare Materials

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4D-Printed MXene-Based Artificial Nerve Guidance Conduit for Enhanced Regeneration of Peripheral Nerve Injuries
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2024-05-28 , DOI: 10.1002/adhm.202401093
Zhilong Wang ₁ , Yan Zheng ₁ , Liang Qiao ₁ , Yuanya Ma ₁ , Huajing Zeng ₁ , Jiachen Liang ₁ , Qian Ye ₁ , Kuangyu Shen ₂ , Bin Liu ₁ , Luyi Sun ₂ , Zengjie Fan ₁

Affiliation

Repairing larger defects (>5 mm) in peripheral nerve injuries (PNIs) remains a significant challenge when using traditional artificial nerve guidance conduits (NGCs). A novel approach that combines 4D printing technology with poly(L-lactide-co-trimethylene carbonate) (PLATMC) and Ti₃C₂T_x MXene nanosheets is proposed, thereby imparting shape memory properties to the NGCs. Upon body temperature activation, the printed sheet-like structure can quickly self-roll into a conduit-like structure, enabling optimal wrapping around nerve stumps. This design enhances nerve fixation and simplifies surgical procedures. Moreover, the integration of microchannel expertly crafted through 4D printing, along with the incorporation of MXene nanosheets, introduces electrical conductivity. This feature facilitates the guided and directional migration of nerve cells, rapidly accelerating the healing of the PNI. By leveraging these advanced technologies, the developed NGCs demonstrate remarkable potential in promoting peripheral nerve regeneration, leading to substantial improvements in muscle morphology and restored sciatic nerve function, comparable to outcomes achieved through autogenous nerve transplantation.

中文翻译：

4D 打印基于 MXene 的人工神经引导导管，用于增强周围神经损伤的再生

使用传统的人工神经引导导管 (NGC) 时，修复周围神经损伤 (PNI) 中的较大缺损 (>5 mm) 仍然是一个重大挑战。提出了一种将 4D 打印技术与聚（L-丙交酯-共-三亚甲基碳酸酯）（PLATMC）和 Ti ₃ C ₂ T _x MXene 纳米片相结合的新方法，从而赋予 NGC 形状记忆特性。当体温激活时，打印的片状结构可以快速自动卷成导管状结构，从而能够最佳地包裹神经残端。这种设计增强了神经固定并简化了手术程序。此外，通过 4D 打印精心制作的微通道的集成，以及 MXene 纳米片的结合，引入了导电性。这一特性有利于神经细胞的引导和定向迁移，迅速加速 PNI 的愈合。通过利用这些先进技术，所开发的NGC在促进周围神经再生方面表现出巨大的潜力，从而显着改善肌肉形态并恢复坐骨神经功能，与通过自体神经移植获得的结果相当。

更新日期：2024-05-28

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