Few studies have focused on the association between clonal hematopoiesis of indeterminate potential (CHIP) and β-amyloid (Aβ) deposition in the brain, which causes Alzheimer's disease. We aimed to investigate the potential role of CHIP in brain Aβ deposition in Korean patients. We enrolled 58 Korean patients over 50 yrs of age with cognitive impairment who underwent brain Aβ positron emission tomography. We explored CHIP in their peripheral blood using deep-targeted next-generation sequencing. Irrespective of the presence or absence of brain Aβ deposition, mutations in DNMT3A and the C:G>T:A single-nucleotide variants were identified as the primary characteristics, which reflect aged hematopoiesis in the study population. Multivariate logistic regression revealed that the presence of CHIP was not associated with brain Aβ deposition. As both CHIP and brain Aβ deposition are associated with aging, further research is required to elucidate their possible interplay.

中文翻译：

---

韩国认知障碍患者不确定电位克隆造血与脑 β-淀粉样蛋白沉积之间的关联。


很少有研究关注不确定潜能克隆造血 (CHIP) 与大脑中 β-淀粉样蛋白 (Aβ) 沉积之间的关联，而β-淀粉样蛋白 (Aβ) 沉积会导致阿尔茨海默病。我们的目的是研究 CHIP 在韩国患者脑部 Aβ 沉积中的潜在作用。我们招募了 58 名 50 岁以上患有认知障碍的韩国患者，他们接受了脑部 Aβ 正电子发射断层扫描。我们使用深度靶向下一代测序技术在他们的外周血中探索了 CHIP。无论脑内是否存在 Aβ 沉积， DNMT3A和 C:G>T:A 单核苷酸变异的突变都被确定为主要特征，反映了研究人群中老年造血功能。多变量逻辑回归显示 CHIP 的存在与脑 Aβ 沉积无关。由于 CHIP 和大脑 Aβ 沉积都与衰老相关，因此需要进一步的研究来阐明它们可能的相互作用。