Illuminating the path to pancreatic cancer,Cell Research

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Illuminating the path to pancreatic cancer
Cell Research ( IF 28.1 ) Pub Date : 2024-05-27 , DOI: 10.1038/s41422-024-00982-9
Hiroyuki Kato _{1,

2,

3} , Nabeel Bardeesy _{1,

2,

3}

Affiliation

Braxton and colleagues used 3D histological reconstruction and multi-region genomic analysis to understand the microanatomy and model the progression of pancreatic intraepithelial neoplasias (PanINs), precursors of pancreatic ductal adenocarcinoma (PDAC). Their study revealed the unexpected prevalence, spatial distribution, and genetic heterogeneity of PanINs, illuminating their developmental trajectories toward PDAC.

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