The present study sought to assess the effects of manganese complexes with lysine and glutamic acid (Mn-LG) as manganese (Mn) sources on growth performance, trace element deposition, antioxidant capacity, and metacarpal strength in weaned piglets. The study involved 288 healthy Duroc × Landrace × Yorkshire piglets that were weaned at 25–28 days of age and weighed 8.66±0.96 kg. These piglets were randomly divided into six groups: a control group (Mn-LG-0, receiving a basal diet without Mn supplementation), a Mn sulfate group (basal diet supplemented with 40 mg·kg-1 diet of Mn, Mn-S-40 group), and four Mn-LG groups (Mn-LG-20, Mn-LG-40, Mn-LG-60, Mn-LG-80, supplemented with 20, 40, 60, and 80 mg·kg-1 Mn from Mn-LG in the basal diet). Grouping began at weaning as the 0th day of the experiment. The corn–soybean-based basal diet during the early (d 0–14) and late (d 15–42) phases of the experiment contained 20.88 and 30.12 mg·kg-1 Mn, respectively. Blood samples were collected on days 14 and 42, and pigs were sacrificed for sample collection on day 42. The results indicated no significant differences in average daily gain, average daily feed intake, or feed-to-gain ratio among the groups (P > 0.05). The diarrhea rates of all Mn-LG groups and the Mn-S-40 group were significantly lower in the 0–14 d and during the entire experimental period than in the Mn-LG-0 group (P < 0.001). The Mn-LG-40 group exhibited a significant increase in liver Mn concentration and serum Mn superoxide dismutase (Mn-SOD) activity on d 42 (P < 0.01), as well as a significant decrease in fecal Mn concentration (P < 0.05), compared to those of the Mn-S-40 group. Significant differences (P < 0.05) were detected in the serum, liver, and fecal Mn concentrations, as well as in the serum and liver Mn-SOD activity, across the different Mn-LG groups. The serum and fecal Mn concentrations and serum Mn-SOD activity increased linearly or quadratically (P < 0.01) with increasing Mn-LG supplementation. No significant differences (P > 0.05) were found in kidney, heart, or metacarpal bone Mn concentrations or in bone strength indices. In summary, compared with the Mn-LG-0 diet, dietary supplementation with Mn-LG enhanced serum Mn deposition and Mn-SOD activity and decreased the incidence of diarrhea. Additionally, the fecal Mn concentration was lower in the Mn-LG group than in the inorganic group at equivalent dosages.

中文翻译：

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赖氨酸和谷氨酸锰络合物对断奶仔猪生长性能、锰沉积和排放、抗氧化能力和掌骨强度的影响


本研究旨在评估赖氨酸和谷氨酸的锰络合物（Mn-LG）作为锰（Mn）源对断奶仔猪生长性能、微量元素沉积、抗氧化能力和掌骨强度的影响。该研究涉及 288 头健康的杜洛克×长白×约克夏仔猪，这些仔猪在 25-28 日龄断奶，体重为 8.66±0.96 公斤。将仔猪随机分为六组：对照组（Mn-LG-0，基础日粮中不添加锰），硫酸锰组（基础日粮中添加40 mg·kg-1 Mn、Mn-S -40组）和四个Mn-LG组（Mn-LG-20、Mn-LG-40、Mn-LG-60、Mn-LG-80，补充有20、40、60和80 mg·kg- 1 Mn 来自基础饮食中的 Mn-LG）。分组在实验第0天断奶时开始。实验早期（d 0-14）和后期（d 15-42）以玉米-大豆为主的基础日粮分别含有 20.88 和 30.12 mg·kg-1 Mn。第14天和第42天采集血样，第42天处死猪进行样品采集。结果表明，各组之间的平均日增重、平均日采食量或料增比没有显着差异（P% 3E 0.05）。所有Mn-LG组和Mn-S-40组在0-14天和整个实验期间的腹泻率均显着低于Mn-LG-0组（P％3C 0.001）。 Mn-LG-40组在第42天表现出肝脏锰浓度和血清锰超氧化物歧化酶（Mn-SOD）活性显着增加（P％3C 0.01），以及粪便锰浓度显着降低（P％3C） 0.05），与 Mn-S-40 组相比。显着差异 (P < 0.05）在不同 Mn-LG 组的血清、肝脏和粪便 Mn 浓度以及血清和肝脏 Mn-SOD 活性中进行了检测。随着 Mn-LG 补充量的增加，血清和粪便 Mn 浓度以及血清 Mn-SOD 活性呈线性或二次方增加 (P < 0.01)。肾脏、心脏或掌骨的锰浓度或骨强度指数没有发现显着差异（P> 0.05）。总之，与Mn-LG-0饮食相比，饮食中添加Mn-LG可增强血清Mn沉积和Mn-SOD活性，并降低腹泻发生率。此外，在同等剂量下，Mn-LG组的粪便锰浓度低于无机组。