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Enhanced hexanoyl glycol chitosan/tannic acid thermogels: Customizable physico-mechanical and biofunctional characteristics for biomedical applications
Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2024-05-20 , DOI: 10.1016/j.cej.2024.152286
Seo Yeong Park , Sunhee Kim , Se Yeon Shin , Woo Kyung Cho , Kang Moo Huh
Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2024-05-20 , DOI: 10.1016/j.cej.2024.152286
Seo Yeong Park , Sunhee Kim , Se Yeon Shin , Woo Kyung Cho , Kang Moo Huh
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This study introduces HGC/TA thermogels, innovative thermosensitive hydrogels developed by integrating tannic acid (TA), a natural polyphenolic compound, into hexanoyl glycol chitosan (HGC). This unique formulation not only enhances the mechanical strength of the thermogels but also incorporates the beneficial physicochemical and biological properties of TA. Compared to conventional thermogels, including pure HGC variants, HGC/TA thermogels demonstrate significantly enhanced storage modulus and compressive strength, remarkable self-healing abilities, increased mucoadhesion, improved stability, and tunable degradation rates, all while being minimally cytotoxic. Moreover, these thermogels exhibit notable antioxidant properties, effectively counteracting free radicals, and display significant antibacterial activity against both Gram-negative E. coli and Gram-positive S. aureus . The ability to tailor the physico-mechanical and biological functions of HGC/TA thermogels by varying the TA concentration makes them highly versatile, marking them as ideal for diverse biomedical applications, particularly in wound care and tissue engineering.
中文翻译:
增强型己二醇壳聚糖/单宁酸热凝胶:用于生物医学应用的可定制物理机械和生物功能特性
本研究介绍了 HGC/TA 热凝胶,这是一种通过将天然多酚化合物单宁酸 (TA) 整合到己酰二醇壳聚糖 (HGC) 中而开发的创新热敏水凝胶。这种独特的配方不仅增强了热凝胶的机械强度,还结合了 TA 的有益物理化学和生物特性。与传统的热凝胶(包括纯 HGC 变体)相比,HGC/TA 热凝胶表现出显著增强的储能模量和抗压强度、显著的自愈能力、增强的粘膜粘附性、更高的稳定性和可调的降解速率,同时具有最小的细胞毒性。此外,这些热凝胶表现出显着的抗氧化特性,有效对抗自由基,并对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌表现出显着的抗菌活性。通过改变 TA 浓度来定制 HGC/TA 热凝胶的物理机械和生物功能的能力使其具有高度的通用性,使其成为各种生物医学应用的理想选择,特别是在伤口护理和组织工程中。
更新日期:2024-05-20
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
增强型己二醇壳聚糖/单宁酸热凝胶:用于生物医学应用的可定制物理机械和生物功能特性
本研究介绍了 HGC/TA 热凝胶,这是一种通过将天然多酚化合物单宁酸 (TA) 整合到己酰二醇壳聚糖 (HGC) 中而开发的创新热敏水凝胶。这种独特的配方不仅增强了热凝胶的机械强度,还结合了 TA 的有益物理化学和生物特性。与传统的热凝胶(包括纯 HGC 变体)相比,HGC/TA 热凝胶表现出显著增强的储能模量和抗压强度、显著的自愈能力、增强的粘膜粘附性、更高的稳定性和可调的降解速率,同时具有最小的细胞毒性。此外,这些热凝胶表现出显着的抗氧化特性,有效对抗自由基,并对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌表现出显着的抗菌活性。通过改变 TA 浓度来定制 HGC/TA 热凝胶的物理机械和生物功能的能力使其具有高度的通用性,使其成为各种生物医学应用的理想选择,特别是在伤口护理和组织工程中。