Nature Reviews Urology ( IF 12.1 ) Pub Date : 2024-05-23 , DOI: 10.1038/s41585-024-00887-7 Olaf P J Vrooman 1 , Philip E V van Kerrebroeck 2 , Michael R van Balken 3 , Gommert A van Koeveringe 2 , Mohammad S Rahnama'i 4, 5
Nocturia, the need to urinate at night, is a common symptom in patients with obstructive sleep apnoea (OSA). Continuous positive airway pressure treatment can reduce nocturia in some patients, but the underlying mechanisms are complex and not fully understood. OSA affects the autonomic nervous system, oxidative stress and endothelial damage. Furthermore, the commonly held theory attributing polyuria to a false signal of cardiac overload and response natriuresis has limitations. A comprehensive approach to the management of nocturia in OSA, considering factors such as comorbidities, medication use, alcohol consumption and lifestyle, is needed. Effective management of nocturia in OSA requires a multidisciplinary approach, and urologists should be aware of the potential effect of OSA on physiology and refer patients for further testing at a sleep centre. In addition to continuous positive airway pressure, other interventions such as oral appliances and surgical obstruction treatment could be beneficial for some patients. Overall, understanding the complex interplay between OSA and nocturia is crucial for optimizing patient outcomes.
中文翻译:
夜尿和阻塞性睡眠呼吸暂停
夜尿,即夜间排尿的需要,是阻塞性睡眠呼吸暂停 (OSA) 患者的常见症状。持续气道正压通气治疗可以减少一些患者的夜尿,但其潜在机制很复杂,尚不完全清楚。OSA 影响自主神经系统、氧化应激和内皮损伤。此外,将多尿归因于心脏超负荷和反应性利钠的错误信号的普遍理论具有局限性。需要一种全面的方法来管理 OSA 中的夜尿症,同时考虑合并症、药物使用、饮酒和生活方式等因素。OSA 中夜尿症的有效管理需要多学科方法,泌尿科医生应了解 OSA 对生理学的潜在影响,并将患者转诊至睡眠中心进行进一步检查。除了持续的气道正压通气外,其他干预措施(如口腔矫治器和手术梗阻治疗)可能对某些患者有益。总体而言,了解 OSA 和夜尿症之间的复杂相互作用对于优化患者预后至关重要。